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Metformin lactic acidosis — GPhC CRA MCQ

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HardAdverse Drug Reactions and SafetyMetformin lactic acidosisGPhC CRA

A 48-year-old woman taking metformin presents with severe vomiting, abdominal pain, deep breathing and marked fatigue after several days of dehydration. She has CKD stage 3b. What is the most appropriate action?

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Correct answer: E — Refer urgently for possible lactic acidosis

Metformin-associated lactic acidosis is rare but serious, and risk increases with renal impairment and dehydration. Deep breathing, vomiting and severe fatigue are concerning features. Urgent medical assessment is needed.

Reference: BNF; NICE CKS