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Fluoxetine switching — GPhC CRA MCQ

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ModerateCNS TherapeuticsFluoxetine switchingGPhC CRA

A 22-year-old woman taking fluoxetine 20mg daily asks to switch to another antidepressant because of sexual dysfunction. She asks whether she can start the new medicine tomorrow if the GP prescribes it. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Fluoxetine has a long half-life and switching plans need prescriber guidance

Fluoxetine and its active metabolite have long half-lives, so interactions can persist after stopping. Switching to certain antidepressants, especially MAOIs, requires an appropriate washout period. The patient should not self-switch and should discuss options with the prescriber.

Reference: BNF; NICE CKS