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SSRI onset of action — GPhC CRA MCQ

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EasyCNS TherapeuticsSSRI onset of actionGPhC CRA

A 33-year-old woman started sertraline 50mg daily for depression 10 days ago. She says nausea has improved but her mood is unchanged. She denies suicidal thoughts and asks whether the tablets are working. What would you advise the patient?

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Correct answer: A — Continue treatment and arrange review because benefit may take several weeks

SSRIs commonly take several weeks to produce meaningful improvement in mood. Early adverse effects such as nausea may settle before antidepressant benefit is felt. The patient should be advised about follow-up, adherence and seeking urgent help if mood worsens or suicidal thoughts occur.

Reference: BNF; NICE CKS