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Methotrexate weekly dosing — GPhC CRA MCQ

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HardMusculoskeletal TherapeuticsMethotrexate weekly dosingGPhC CRA

A 52-year-old woman with rheumatoid arthritis presents a prescription for methotrexate 2.5mg tablets, eight tablets once weekly. She says she sometimes forgets and takes one tablet each morning instead. What is the most appropriate action?

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Correct answer: BStop supply until the dosing misunderstanding is resolved with urgent counselling and prescriber contact

Methotrexate dosing errors can be fatal, and it must be taken once weekly when prescribed for rheumatoid arthritis. Daily dosing is a serious misunderstanding requiring urgent intervention before supply. Counselling should confirm the weekly day, folic acid schedule, monitoring and toxicity symptoms.

Reference: BNF; MHRA safety advice