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Lithium and thiazide-like diuretics — GPhC CRA MCQ

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HardDrug InteractionsLithium and thiazide-like diureticsGPhC CRA

A 63-year-old man takes lithium for bipolar disorder. He has been prescribed indapamide for hypertension. His lithium level was stable at the last clinic review. What is the most important interaction to flag?

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Correct answer: D — Thiazide-like diuretics can increase lithium levels and toxicity risk

Thiazide and thiazide-like diuretics can reduce lithium clearance and increase lithium concentrations. Toxicity can be serious and may present with tremor, ataxia, vomiting or confusion. The prescriber should review the antihypertensive choice and monitoring plan.

Reference: BNF