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Carbimazole agranulocytosis — GPhC CRA MCQ

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HardEndocrine TherapeuticsCarbimazole agranulocytosisGPhC CRA

A 33-year-old woman taking carbimazole for Graves' disease presents with a sore throat, fever and mouth ulcers. She asks for advice because she is due to collect her repeat prescription today. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Advise urgent full blood count and withhold carbimazole pending medical advice

Carbimazole can cause agranulocytosis, which may present with sore throat, fever or mouth ulcers. The patient needs urgent full blood count and medical advice. Continuing treatment without assessment could delay recognition of a serious adverse reaction.

Reference: BNF; NICE CKS