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Simvastatin and amlodipine — GPhC CRA MCQ

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ModerateDrug InteractionsSimvastatin and amlodipineGPhC CRA

A 61-year-old man takes simvastatin 40mg nightly and has been prescribed amlodipine 10mg daily. He has no muscle symptoms. The prescription is otherwise appropriate. What is the most appropriate action?

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Correct answer: C — Contact the prescriber because simvastatin dose should not exceed the recommended limit with amlodipine

Amlodipine increases simvastatin exposure and myopathy risk. Simvastatin dose should be limited when used with amlodipine, or an alternative statin considered. The pharmacist should contact the prescriber rather than dispensing a potentially excessive interacting dose.

Reference: BNF