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SSRI and NSAID bleeding — GPhC CRA MCQ

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ModerateDrug InteractionsSSRI and NSAID bleedingGPhC CRA

A 49-year-old woman taking sertraline asks to buy ibuprofen for period pain. She has a history of gastritis and takes no PPI. What is the most important interaction to flag?

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Correct answer: C — SSRI with NSAID increases gastrointestinal bleeding risk

SSRIs can increase bleeding risk, and the risk is higher when combined with NSAIDs, especially in patients with gastrointestinal history. Alternative analgesia or gastroprotection may need consideration. The pharmacist should assess severity and duration of pain and refer if needed.

Reference: BNF