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Gabapentin renal dosing — GPhC CRA MCQ

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ModerateRenal and Hepatic ImpairmentGabapentin renal dosingGPhC CRA

A 82-year-old man with eGFR 18mL/min/1.73m2 is prescribed gabapentin 300mg three times daily for neuropathic pain. He is drowsy and unsteady after two days. What is the most appropriate alternative?

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Correct answer: E — Query dose accumulation and refer for review

Gabapentin is renally cleared and requires dose adjustment in renal impairment. Drowsiness and unsteadiness may reflect excessive exposure, particularly in older people. The prescriber should review the dose and falls risk.

Reference: BNF