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Domperidone cardiac risk — GPhC CRA MCQ

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HardGastro-intestinal TherapeuticsDomperidone cardiac riskGPhC CRA

A 70-year-old man is prescribed domperidone 10mg three times daily for nausea. He also takes amiodarone and has a history of arrhythmia. The prescription is for 4 weeks. What is the most important interaction to flag?

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Correct answer: B — Domperidone may increase cardiac arrhythmia risk in this patient

Domperidone is associated with QT prolongation and serious cardiac arrhythmia risk, especially in older patients, higher exposure and those taking QT-prolonging medicines. Amiodarone and previous arrhythmia make the prescription concerning. Duration and indication should be reviewed by the prescriber.

Reference: BNF; MHRA Drug Safety Update