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Lamotrigine rash — GPhC CRA MCQ

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EasyCNS TherapeuticsLamotrigine rashGPhC CRA

A 37-year-old man started lamotrigine three weeks ago for epilepsy. He presents with a widespread rash, fever and mouth ulcers. He has not missed any doses. What is the most appropriate action?

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Correct answer: B — Refer urgently for assessment of a serious skin reaction

Lamotrigine can rarely cause serious skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Rash with fever and mucosal involvement is a red flag and requires urgent medical assessment. The patient should not be reassured or advised to continue without urgent review.

Reference: BNF