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Paracetamol in liver disease — GPhC CRA MCQ

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ModerateRenal and Hepatic ImpairmentParacetamol in liver diseaseGPhC CRA

A 58-year-old man with chronic liver disease asks how much paracetamol he can take for dental pain. He drinks no alcohol currently but has abnormal liver function tests and low body weight. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Refer for individual dosing advice rather than recommending maximum OTC dosing

Paracetamol can often be used in liver disease, but dose limits may need individual adjustment based on severity, alcohol use, weight and nutritional status. Recommending maximum OTC dosing without assessment may be unsafe. Dental pain also needs dental referral for definitive care.

Reference: BNF; NICE CKS