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Clozapine constipation safety — GPhC CRA MCQ

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HardAdverse Drug Reactions and SafetyClozapine constipation safetyGPhC CRA

A patient taking clozapine reports no bowel movement for five days, abdominal pain and vomiting. He asks for senna because this happens sometimes. What is the most appropriate action?

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Correct answer: B — Refer urgently because clozapine-related gastrointestinal hypomotility can be life-threatening

Clozapine can cause severe gastrointestinal hypomotility, ileus and bowel obstruction. Abdominal pain, vomiting and prolonged constipation are red flags. Urgent assessment is needed rather than simple OTC treatment.

Reference: BNF; MHRA Drug Safety Update