skip to main content

PDE5 inhibitor and nitrates — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

EasyDrug InteractionsPDE5 inhibitor and nitratesGPhC CRA

A man prescribed GTN spray for angina asks whether he can use sildenafil bought online for erectile dysfunction. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Sildenafil must not be used with nitrates because of severe hypotension risk

PDE5 inhibitors and nitrates both increase vasodilation and can cause profound hypotension when combined. Patients using nitrates need medical advice before erectile dysfunction treatment. Online supply may miss important safety checks.

Reference: BNF