A patient taking ramipril and spironolactone receives trimethoprim for UTI. Baseline potassium is 4.9 mmol/L and eGFR is 42 mL/min. What should the

Question

A patient taking ramipril and spironolactone receives trimethoprim for UTI. Baseline potassium is 4.9 mmol/L and eGFR is 42 mL/min. What should the pharmacist do?

Accepted Answer

Query trimethoprim; the combination raises severe hyperkalaemia risk

Answer

Reduce spironolactone temporarily without reviewing the antibiotic choice

Answer

Supply trimethoprim after separating it from spironolactone by six hours

Answer

Replace ramipril with losartan while supplying the prescribed trimethoprim

Answer

Supply trimethoprim with potassium and renal testing after three days

Hyperkalaemia symptoms — GPhC CRA MCQ

A patient taking ramipril and spironolactone receives trimethoprim for UTI. Baseline potassium is 4.9 mmol/L and eGFR is 42 mL/min. What should the pharmacist do?