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MAOI and decongestants — GPhC CRA MCQ

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ModerateDrug InteractionsMAOI and decongestantsGPhC CRA

A patient taking phenelzine asks for pseudoephedrine tablets for nasal congestion before a flight. What is the most important interaction to flag?

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Correct answer: D — Pseudoephedrine can interact with MAOIs and cause hypertensive reactions

MAOIs interact with sympathomimetic decongestants, risking significant hypertension. Safer options such as saline preparations may be suitable depending on symptoms. The pharmacist should avoid supplying pseudoephedrine in this context.

Reference: BNF