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Colchicine interactions — GPhC CRA MCQ

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HardMusculoskeletal TherapeuticsColchicine interactionsGPhC CRA

A patient taking colchicine for gout is prescribed clarithromycin for pneumonia. He has eGFR 45 mL/min/1.73 m² and asks if both can be taken. What is the most important interaction to flag?

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Correct answer: C — Flag a serious interaction because clarithromycin can increase colchicine toxicity

Clarithromycin inhibits pathways involved in colchicine clearance and can precipitate serious toxicity, especially in renal impairment. The combination should be avoided or managed with specialist advice. Dose separation is not sufficient.

Reference: BNF