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Doxazosin postural hypotension — GPhC CRA MCQ

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EasyCardiovascular TherapeuticsDoxazosin postural hypotensionGPhC CRA

A 76-year-old man starts doxazosin 1 mg at night for resistant hypertension. He asks why the first dose is taken at bedtime and whether driving home after the first dose is sensible. What would you advise the patient?

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Correct answer: D — Warn about postural dizziness and advise taking the first dose at bedtime

Alpha-blockers can cause postural hypotension and first-dose dizziness. Taking the first dose at bedtime and standing slowly can reduce falls risk. Concurrent vasodilators such as sildenafil may worsen hypotension.

Reference: BNF