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SSRI and NSAID bleeding risk — GPhC CRA MCQ

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ModerateCNS TherapeuticsSSRI and NSAID bleeding riskGPhC CRA

A 54-year-old woman takes fluoxetine and asks to buy naproxen for back pain. She has a previous gastric ulcer and takes no gastroprotection. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Flag increased gastrointestinal bleeding risk and consider safer analgesia or referral

SSRIs can increase bleeding risk, and NSAIDs further increase gastrointestinal bleeding risk, especially with ulcer history. Safer analgesia or prescriber review is appropriate. Aspirin would add further bleeding risk.

Reference: BNF