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Methotrexate weekly dosing — GPhC CRA MCQ

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EasyMusculoskeletal TherapeuticsMethotrexate weekly dosingGPhC CRA

A patient newly prescribed methotrexate 10 mg weekly for rheumatoid arthritis says she has been taking one tablet every morning for four days because the label was unclear. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Refer urgently for assessment and clarify once-weekly dosing

Low-dose methotrexate for inflammatory disease is taken once weekly, and accidental daily dosing can be life-threatening. The patient needs urgent clinical assessment for toxicity and blood tests. Clear labelling and counselling are critical.

Reference: BNF; NPSA guidance