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ACE inhibitor angioedema — GPhC CRA MCQ

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HardAdverse Drug Reactions and SafetyACE inhibitor angioedemaGPhC CRA

A 58-year-old woman taking ramipril develops lip and tongue swelling. She asks whether she can take an antihistamine and continue ramipril tomorrow. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Refer urgently and advise ACE inhibitor review because angioedema can threaten the airway

ACE inhibitor-induced angioedema can be life-threatening and requires urgent assessment if airway involvement is possible. The ACE inhibitor should be reviewed and generally avoided after angioedema. Antihistamines do not make continued exposure safe.

Reference: BNF; NICE CKS