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PPI step-down — GPhC CRA MCQ

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EasyGastrointestinal TherapeuticsPPI step-downGPhC CRA

A 46-year-old man has taken omeprazole 20 mg daily for reflux for six months. Symptoms are controlled and he asks whether to continue indefinitely. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Step down to the lowest effective PPI regimen

PPIs should be reviewed periodically and used at the lowest effective dose when long-term therapy is not clearly required. Step-down or on-demand use may be suitable for controlled reflux. Long-term high-dose use without review increases avoidable exposure.

Reference: https://www.pharmacyregulation.org/students-and-trainees/pharmacist-education-and-training/registration-assessment