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Aciclovir renal dose and hydration — GPhC CRA MCQ

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ModerateRenal and Hepatic ImpairmentAciclovir renal dose and hydrationGPhC CRA

A 70-year-old man with eGFR 33 mL/min/1.73 m² is prescribed aciclovir for shingles. He asks why the dose has been reduced and why hydration is mentioned. What is the most appropriate alternative?

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Correct answer: A — Renal dose adjustment and adequate hydration reduce aciclovir toxicity risk

Aciclovir is renally cleared and dose adjustment may be required in renal impairment. Adequate hydration reduces risk of crystal nephropathy. The patient should follow the prescribed adjusted regimen and seek help if deteriorating.

Reference: BNF