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MAOI dietary interaction — GPhC CRA MCQ

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HardCNS TherapeuticsMAOI dietary interactionGPhC CRA

A patient taking phenelzine asks about attending a wine and cheese evening. The medicine was started after several antidepressants failed. What would you advise the patient?

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Correct answer: C — Avoid tyramine-rich foods and drinks because of hypertensive crisis risk

MAOIs such as phenelzine interact with tyramine-rich foods and some sympathomimetic medicines, risking hypertensive crisis. Patients need detailed dietary and interaction counselling. Stopping for a single day does not remove the risk.

Reference: BNF