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Febuxostat cardiovascular caution — GPhC CRA MCQ

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HardMusculoskeletal TherapeuticsFebuxostat cardiovascular cautionGPhC CRA

A 61-year-old man with gout and previous myocardial infarction cannot tolerate allopurinol. A prescriber asks whether febuxostat is a straightforward substitute. What is the most appropriate alternative?

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Correct answer: DUse caution and consider specialist advice because febuxostat has cardiovascular safety considerations

Febuxostat can be an alternative urate-lowering medicine but cardiovascular history requires careful consideration. Treatment choice should account for comorbidities, renal function and specialist guidance where needed. Aspirin is not urate-lowering treatment for gout prevention.

Reference: BNF; NICE CKS