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Opioids in hepatic impairment — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentOpioids in hepatic impairmentGPhC CRA

A patient with decompensated liver cirrhosis asks for advice about co-codamol bought previously for back pain. He is jaundiced and has had recent confusion. What is the most appropriate alternative?

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Correct answer: E — Refer for medical advice before using opioid-containing analgesics

Cirrhosis and encephalopathy increase risk from sedating medicines such as opioids. NSAIDs and high-dose paracetamol also require caution in advanced liver disease. Analgesia should be individualised with medical input.

Reference: BNF