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Nitrofurantoin renal function — GPhC CRA MCQ

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ModerateInfectionsNitrofurantoin renal functionGPhC CRA

A 79-year-old woman is prescribed nitrofurantoin 100 mg modified-release twice daily for UTI. Her shared record shows eGFR 28 mL/min/1.73 m² and fever with flank pain. What is the most appropriate action?

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Correct answer: B — Query the prescription and refer because renal impairment and upper UTI features are concerns

Nitrofurantoin is unsuitable for suspected upper UTI and has renal function restrictions because urinary concentrations may be inadequate and toxicity risk increases. Fever and flank pain need clinical assessment. The prescription should be queried.

Reference: BNF; NICE CKS