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Theophylline and ciprofloxacin — GPhC CRA MCQ

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HardDrug InteractionsTheophylline and ciprofloxacinGPhC CRA

A patient taking theophylline modified-release tablets is prescribed ciprofloxacin for a complicated UTI. He reports previous palpitations on theophylline. What is the most important interaction to flag?

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Correct answer: C — Ciprofloxacin can increase theophylline levels and toxicity risk

Ciprofloxacin can inhibit theophylline metabolism and increase toxicity risk. Symptoms may include nausea, tremor, palpitations and seizures. An alternative antibiotic or monitoring advice should be considered.

Reference: BNF