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Clopidogrel and omeprazole — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsClopidogrel and omeprazoleGPhC CRA

A 66-year-old man taking clopidogrel after a stroke buys omeprazole for dyspepsia. He has no alarm symptoms and asks whether it is suitable. What is the most important interaction to flag?

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Correct answer: B — Omeprazole may reduce clopidogrel activation, so recommend an alternative such as lansoprazole if a PPI is needed

Omeprazole and esomeprazole can inhibit CYP2C19 and reduce activation of clopidogrel. If a PPI is needed, alternatives such as lansoprazole or pantoprazole are commonly preferred. Urgent referral is not required without concerning symptoms, but counselling and prescriber communication are appropriate.

Reference: BNF; MHRA Drug Safety Update