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SSRIs and linezolid — GPhC CRA MCQ

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HardDrug InteractionsSSRIs and linezolidGPhC CRA

A hospital discharge prescription includes linezolid for a patient taking fluoxetine. The patient says fluoxetine was taken yesterday. What is the most important interaction to flag?

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Correct answer: C — Flag risk of serotonin toxicity and seek specialist advice before supply

Linezolid has monoamine oxidase inhibitor activity and can interact with serotonergic medicines such as SSRIs. Fluoxetine has a long half-life, so recent use remains relevant. Specialist advice is required.

Reference: BNF