DAPT after ACS — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardCardiovascular TherapeuticsDAPT after ACSGPhC CRA

A patient with a coronary stent taking aspirin and ticagrelor is prescribed clarithromycin. Which issue requires immediate review?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Increased ticagrelor exposure and bleeding

Clarithromycin strongly inhibits CYP3A4 and can increase ticagrelor exposure, adding bleeding risk to dual antiplatelet therapy. The indication and a non-interacting antibiotic should be discussed urgently with the prescriber. The patient must not stop antiplatelet treatment independently because of stent-thrombosis risk.

Reference: https://bnf.nice.org.uk/interactions/