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Rifampicin and contraception — GPhC CRA MCQ

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HardInfectionsRifampicin and contraceptionGPhC CRA

A woman using a combined oral contraceptive is prescribed rifampicin for a specialist infection regimen. She asks whether her contraception is affected. What is the most important interaction to flag?

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Correct answer: B — Rifampicin is a potent enzyme inducer and can reduce hormonal contraceptive efficacy

Rifampicin is a strong enzyme inducer and can reduce exposure to many hormonal contraceptives. The patient needs advice about effective alternative contraception during and after treatment according to guidance. Dose separation does not overcome enzyme induction.

Reference: BNF; FSRH guidance