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Sacubitril valsartan washout — GPhC CRA MCQ

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HardCardiovascular TherapeuticsSacubitril valsartan washoutGPhC CRA

A patient with heart failure brings a discharge prescription for sacubitril/valsartan. His repeat medicines show ramipril was supplied last week and he is unsure when it was stopped. What is the most important interaction to flag?

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Correct answer: A — Confirm a 36-hour washout from ramipril before starting sacubitril/valsartan

Sacubitril/valsartan must not be used with an ACE inhibitor because of increased angioedema risk. A washout period is required after stopping an ACE inhibitor before initiation. The pharmacist should clarify timing before supply or administration.

Reference: BNF