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Azole antifungal and statin — GPhC CRA MCQ

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ModerateDrug InteractionsAzole antifungal and statinGPhC CRA

A patient taking atorvastatin 40 mg daily is prescribed itraconazole capsules for fungal infection. He asks if muscle pain is a concern. What is the most important interaction to flag?

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Correct answer: D — Itraconazole can increase atorvastatin exposure and myopathy risk

Itraconazole is a potent CYP3A4 inhibitor and can increase exposure to atorvastatin, increasing myopathy risk. Depending on need, the statin may be withheld or changed. Patients should report unexplained muscle symptoms.

Reference: BNF