skip to main content

Lamotrigine rash — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardCNS TherapeuticsLamotrigine rashGPhC CRA

A 31-year-old woman recently started lamotrigine and titrated the dose upward. She presents with a spreading rash, fever and mouth ulcers. She asks for antihistamines. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Refer urgently for assessment and advise not taking further doses until reviewed

Rash with systemic features after starting lamotrigine may indicate a serious cutaneous adverse reaction. The patient needs urgent medical assessment and should not simply continue treatment. Antihistamines or topical steroids may delay recognition of a potentially severe reaction.

Reference: BNF