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Simvastatin and grapefruit — GPhC CRA MCQ

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EasyDrug InteractionsSimvastatin and grapefruitGPhC CRA

A man taking simvastatin 40 mg nightly asks whether he can drink grapefruit juice every morning as part of a diet plan. What is the most important interaction to flag?

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Correct answer: D — Grapefruit juice can increase simvastatin exposure and myopathy risk

Grapefruit juice inhibits intestinal CYP3A4 and can increase exposure to simvastatin. This increases the risk of muscle toxicity. Timing separation does not reliably prevent the interaction.

Reference: BNF