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Serotonin syndrome risk — GPhC CRA MCQ

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ModerateCNS TherapeuticsSerotonin syndrome riskGPhC CRA

A man taking sertraline 100 mg daily is prescribed tramadol for acute dental pain. He asks whether he can use both medicines while waiting for extraction. What is the most important interaction to flag?

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Correct answer: A — Flag increased risk of serotonin toxicity and seizures with tramadol

Tramadol has serotonergic activity and can lower seizure threshold. Combined use with SSRIs increases risk of serotonin toxicity and adverse CNS effects. Alternative analgesia or prescriber discussion is safer.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-46