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Macrolide and colchicine — GPhC CRA MCQ

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ModerateDrug InteractionsMacrolide and colchicineGPhC CRA

A patient taking colchicine for gout prophylaxis is prescribed clarithromycin for a chest infection. They have reduced renal function. What is the most important interaction to flag?

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Correct answer: C — Increased colchicine toxicity risk

Clarithromycin can greatly increase colchicine exposure, especially risky with renal impairment. The best answer addresses the key safety, legal or pharmaceutical care issue in the vignette. The other options would either delay appropriate care, create a new risk, or fail to resolve the issue. This is consistent with the cited UK reference for safe pharmacy practice.

Reference: BNF