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Linezolid and SSRI — GPhC CRA MCQ

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HardDrug InteractionsLinezolid and SSRIGPhC CRA

A patient taking fluoxetine is prescribed linezolid by hospital outpatients. They ask why the pharmacist is contacting the prescriber. What is the most important interaction to flag?

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Correct answer: A — Serotonin toxicity risk

Linezolid has monoamine oxidase inhibiting properties and can interact with SSRIs. The best answer addresses the key safety, legal or pharmaceutical care issue in the vignette. The other options would either delay appropriate care, create a new risk, or fail to resolve the issue. This is consistent with the cited UK reference for safe pharmacy practice.

Reference: BNF