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Clozapine and smoking cessation — GPhC CRA MCQ

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ModerateDrug InteractionsClozapine and smoking cessationGPhC CRA

A patient taking clozapine plans to stop smoking today with varenicline. They ask whether clozapine dose needs review. What is the most important interaction to flag?

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Correct answer: C — Increased clozapine concentration after stopping smoking

Stopping smoking can reduce CYP1A2 induction and increase clozapine exposure. The best answer addresses the key safety, legal or pharmaceutical care issue in the vignette. The other options would either delay appropriate care, create a new risk, or fail to resolve the issue. This is consistent with the cited UK reference for safe pharmacy practice.

Reference: BNF