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Responsible pharmacist absence — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardPharmacy Law and EthicsResponsible pharmacist absenceGPhC CRA

A patient with an intracranial haemorrhage took apixaban 10 mg four hours ago. The specialist team has selected andexanet alfa for urgent reversal. Which preparation and administration regimen matches the Ondexxya SmPC?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Use nine 200 mg vials: 800 mg bolus, then 8 mg/min for 120 minutes

Explanation lettering: D = shown as C · E = shown as D · C = shown as E

A is the low-dose regimen used when the apixaban last dose is 5 mg or less. B is not a licensed Ondexxya regimen. C is correct: apixaban above 5 mg taken within eight hours requires the high-dose regimen—an 800 mg bolus followed by 8 mg/min for 120 minutes; the bolus plus 960 mg infusion requires nine 200 mg vials. D combines the high bolus with the low infusion and would underdose. E omits the required infusion and is not an SmPC regimen.

Reference: Ondexxya 200 mg powder for solution for infusion SmPC. https://www.medicines.org.uk/emc/product/10933/smpc