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PDE5 inhibitor and nitrate — GPhC CRA MCQ

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HardDrug InteractionsPDE5 inhibitor and nitrateGPhC CRA

A man using GTN spray asks for sildenafil after seeing an online advert. He last used GTN yesterday for angina. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Severe hypotension from nitrate and PDE5 inhibitor combination

Nitrates and PDE5 inhibitors can cause dangerous additive vasodilation. The best answer addresses the key safety, legal or pharmaceutical care issue in the vignette. The other options would either delay appropriate care, create a new risk, or fail to resolve the issue. This is consistent with the cited UK reference for safe pharmacy practice.

Reference: BNF