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SSRI and NSAID — GPhC CRA MCQ

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ModerateDrug InteractionsSSRI and NSAIDGPhC CRA

A patient taking sertraline asks to buy naproxen for period pain. They have a previous history of gastritis. What is the most important interaction to flag?

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Correct answer: E — Increased gastrointestinal bleeding risk

SSRIs can increase bleeding risk, which is compounded by NSAIDs. The best answer addresses the key safety, legal or pharmaceutical care issue in the vignette. The other options would either delay appropriate care, create a new risk, or fail to resolve the issue. This is consistent with the cited UK reference for safe pharmacy practice.

Reference: BNF