skip to main content

Rifampicin and DOAC — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateDrug InteractionsRifampicin and DOACGPhC CRA

A patient taking apixaban for atrial fibrillation is prescribed rifampicin for a confirmed infection. The GP asks about the main concern. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Reduced apixaban exposure and thrombosis risk

Rifampicin induces enzymes and transporters that can reduce DOAC effect. The best answer addresses the key safety, legal or pharmaceutical care issue in the vignette. The other options would either delay appropriate care, create a new risk, or fail to resolve the issue. This is consistent with the cited UK reference for safe pharmacy practice.

Reference: BNF