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Methotrexate overdose risk — GPhC CRA MCQ

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ModerateMusculoskeletal TherapeuticsMethotrexate overdose riskGPhC CRA

A patient prescribed methotrexate 15 mg once weekly says the label from hospital says to take it on Mondays but the repeat prescription says daily. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: ADo not supply until the dosing discrepancy is clarified urgently

Methotrexate intended for weekly use can cause fatal toxicity if taken daily. The best answer addresses the key safety, legal or pharmaceutical care issue in the vignette. The other options would either delay appropriate care, create a new risk, or fail to resolve the issue. This is consistent with the cited UK reference for safe pharmacy practice.

Reference: BNF; NICE CKS