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Simvastatin and grapefruit — GPhC CRA MCQ

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HardDrug InteractionsSimvastatin and grapefruitGPhC CRA

A patient taking simvastatin 40 mg asks whether grapefruit juice is safe because they drink it each morning. What is the most important interaction to flag?

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Correct answer: D — Increased simvastatin exposure and myopathy risk

Grapefruit can inhibit metabolism of simvastatin. The best answer addresses the key safety, legal or pharmaceutical care issue in the vignette. The other options would either delay appropriate care, create a new risk, or fail to resolve the issue. This is consistent with the cited UK reference for safe pharmacy practice.

Reference: BNF