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ACE inhibitor, diuretic and NSAID — GPhC CRA MCQ

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HardDrug InteractionsACE inhibitor, diuretic and NSAIDGPhC CRA

A patient taking ramipril and bendroflumethiazide asks to buy ibuprofen for a sprained ankle. They are 72 and have previous CKD stage 3. What is the most important interaction to flag?

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Correct answer: D — Acute kidney injury risk from the ACE inhibitor, diuretic and NSAID combination

This combination can reduce renal perfusion and precipitate acute kidney injury. The best answer addresses the key safety, legal or pharmaceutical care issue in the vignette. The other options would either delay appropriate care, create a new risk, or fail to resolve the issue. This is consistent with the cited UK reference for safe pharmacy practice.

Reference: BNF