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Lithium and ibuprofen — GPhC CRA MCQ

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ModerateDrug InteractionsLithium and ibuprofenGPhC CRA

A patient taking lithium wants ibuprofen for dental pain because paracetamol has not helped. Their lithium level was stable last month. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Increased lithium concentration and toxicity risk

NSAIDs can reduce lithium clearance and precipitate toxicity. The best answer addresses the key safety, legal or pharmaceutical care issue in the vignette. The other options would either delay appropriate care, create a new risk, or fail to resolve the issue. This is consistent with the cited UK reference for safe pharmacy practice.

Reference: BNF