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Omeprazole and clopidogrel — GPhC CRA MCQ

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ModerateGastrointestinal TherapeuticsOmeprazole and clopidogrelGPhC CRA

A patient taking clopidogrel after a coronary stent is prescribed omeprazole for reflux. They ask whether it is the safest PPI for them. What is the most important interaction to flag?

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Correct answer: A — Reduced clopidogrel activation and antiplatelet effect

Omeprazole can inhibit CYP2C19 and reduce clopidogrel activation. The best answer addresses the key safety, legal or pharmaceutical care issue in the vignette. The other options would either delay appropriate care, create a new risk, or fail to resolve the issue. This is consistent with the cited UK reference for safe pharmacy practice.

Reference: BNF; NICE CKS