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MAOI interaction — GPhC CRA MCQ

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ModerateCNS TherapeuticsMAOI interactionGPhC CRA

A patient taking phenelzine asks to buy pseudoephedrine for nasal congestion. They say their antidepressant was started by a specialist and works well. Blood pressure is usually normal. What is the most important interaction to flag?

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Correct answer: B — Pseudoephedrine may cause hypertensive crisis with phenelzine

Sympathomimetic decongestants can interact dangerously with MAOIs and may precipitate severe hypertension. The pharmacist should avoid supplying pseudoephedrine and suggest safer symptomatic measures or referral. The other proposed interactions do not represent the main risk.

Reference: BNF